HISTOPATHOLOGICAL CHANGES IN LIVER OF MICE AFTER EXPERIMENTAL ENVENOMATION WITH ANDROCTONUS AMOREUXI SCORPION VENOM

Document Type : Original Article

Authors

1 Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Egypt.

2 Department of Zoology, Faculty of Science, Suez University, Suez, Egypt.

3 Department of Zoology, Faculty of Science, Suez Canal University, Egypt.

Abstract

A total of 78 adult male Albino mice were divided into thirteen groups (6 mice in each). One served as a control group and the other twelve groups were venom treated groups. The mice of treated groups were injected with 0.1 ml saline solution
in which a particular amount of scorpion venom. The first 6 groups were subcutaneously injected with 1/2 LD50 (0.05 g/g body weight), while the other 6 groups were injected with 1/4 LD 50 (0.025 g/g body weight) by the same route.
The animals from each group were anesthetized with ethyl ether and sacrificed at different time intervals (3, 6, 9, 12 hrs, 4 & 7days post toxin administration). The microscopic examination of liver tissue obtained from envenomed animals
showed variable histopathological changes being severely increased with the time interval of envenoming. The most obvious changes in the liver were acute cellular swelling, hydropic degeneration, congestion of central veins and portal blood vessels. Besides, extramedullary hematopoiesis and invaginations in nuclei of hepatic cells, with formation of intranuclear cytoplasmic inclusions were observed.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 43, Issue 2
August 2013
Pages 447-456

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