EVALUATION OF CYCLODEXTRIN (SUGAMMADEX) FOR REVERSAL OF INTENSE NEUROMUSCULAR BLOCK OF ROCURONIUM AND VECURONIUM, EXPERIMENTAL AND CLINICAL STUDIES

Document Type : Original Article

Author

Department of Anesthesia and ICU, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo, Egypt.

Abstract

This study evaluated and explored time course, efficacy, relation, safety, changes in heart rate, and blood pressure after a bolus dose of sugammadex or neostigmine for reversal of a prolonged rocuronium and vecuronium induced neuromuscular
block. A total of 60 patients of both sexes, ‘ASA’ grade I, II and all were scheduled for elective surgery of 30-45 minutes duration. Informed oral consent was obtained from all patients to participate in this study. The results showed statistically significant progressive decrease of heart rate and blood pressure at 2, 5 and 10 minutes when compared to their basal values before anesthesia, then it starts to gain its normal value at 5 and 10 minutes, regardless the dose of sugammadex (effect of anesthesia). Also, heart rate and blood pressure showed statistically non-significant variance between groups of sugammadex when compared at any time of the study with the neostigmine groups (i.e. no effect of the dose on heart rate).

Keywords

Journal of the Egyptian Society of Parasitology
Volume 43, Issue 3
December 2013
Pages 705-714

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