ASSESSMENT OF THE DIAGNOSTIC AND PROGNOSTIC ROLE OF CEREBEROSPINAL FLUID INTERLEUKIN-8 LEVEL IN ADULT PATIENTS WITH MENINGITIS

Document Type : Original Article

Authors

1 Departments of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.

2 Departments of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.

Abstract

Meningitis necessitates immediate diagnosis and therapy. It is important to distingu- ish bacterial from aseptic meningitis, as this help to avoid complications and unnece- ssary antibiotic use. This work assessed the diagnostic and prognostic role of cerebro-spinal fluid interleukin-8 (IL- 8) level in adult patients with meningitis. Ninety adult patients with meningitis were studied. They were divided into 3 groups: bacterial, tuberculous and aseptic meningitis. Full clinical examination and laboratory workup of meningitis were done. Cerebrospinal fluid (CSF) IL-8 levels were assessed. Patients were followed up
till discharge or death. CSF IL-8 level was significantly higher in bacterial and tuberculous meningitis in comparison
to aseptic meningitis. At cut off value 121.77 pg/ml, the area under ROC curve was 0.774 with efficacy 69% for differentiating viral from non-viral meningitis. The test efficacy is low in differentiating tuberculous from bacterial meningitis. There is no correlation of CSF IL-8 levels and disease severity or prognosis.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 46, Issue 2
August 2016
Pages 361-366

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