SABER, A., ABDELWAHAB, A., EL AMIR, A., NASSAR, M., ZOHDI, H. (2017). BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE. Journal of the Egyptian Society of Parasitology, 47(2), 443-458. doi: 10.12816/jesp.2017.77951
AMANY EL SAYED SABER; ABDELWAHAB KHALIL ABDELWAHAB; AZZA MOHAMED EL AMIR; MAMDOUH IBRAHIM NASSAR; HUSSEIN FOUAD ZOHDI. "BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE". Journal of the Egyptian Society of Parasitology, 47, 2, 2017, 443-458. doi: 10.12816/jesp.2017.77951
SABER, A., ABDELWAHAB, A., EL AMIR, A., NASSAR, M., ZOHDI, H. (2017). 'BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE', Journal of the Egyptian Society of Parasitology, 47(2), pp. 443-458. doi: 10.12816/jesp.2017.77951
SABER, A., ABDELWAHAB, A., EL AMIR, A., NASSAR, M., ZOHDI, H. BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE. Journal of the Egyptian Society of Parasitology, 2017; 47(2): 443-458. doi: 10.12816/jesp.2017.77951
BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE
1Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
2Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
3Department of Zoology, Faculty of Science, Cairo University,Giza, Egypt.
4Department of Entomology, Faculty of Science, Cairo University, Giza, Egypt.
Abstract
Entamoeba histolytica is an invasive parasite and results in intestinal inflammation and amebic liver abscess. Metronidazole is the main used drug for amoebiasis in both adults and children. However, metronidazole has some drawbacks such as having potential mutagenic effects in rats as well as the problem of the emergence of drug- resistance species makes the development of other safer drugs for amoebiasis is critical. In this study we assessed the ability of bee venom (BV) loaded chitosan (CS) nanoparticles to treat amoebiasis and that BV has antiamoebic effect as well as it is proved that orally administered BV loaded CS nanoparticles can be a more effective alternative drug for amoebiasis than subcutaneously injected BV.
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