BEE VENOM LOADED CHITOSAN NANOPARTICLES AS TREATMENT FOR AMOEBIASIS IN MICE

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

2 Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

3 Department of Zoology, Faculty of Science, Cairo University,Giza, Egypt.

4 Department of Entomology, Faculty of Science, Cairo University, Giza, Egypt.

Abstract

Entamoeba histolytica is an invasive parasite and results in intestinal inflammation and amebic liver abscess. Metronidazole is the main used drug for amoebiasis in both adults and children. However, metronidazole has some drawbacks such as having potential mutagenic effects in rats as well as the problem of the emergence of drug- resistance species makes the development of other safer drugs for amoebiasis is critical. In this study we assessed the ability of bee venom (BV) loaded chitosan (CS) nanoparticles to treat amoebiasis and that BV has antiamoebic effect as well as it is proved that orally administered BV loaded CS nanoparticles can be a more effective alternative drug for amoebiasis than subcutaneously injected BV.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 47, Issue 2
August 2017
Pages 443-458

Files

Share

How to cite

Statistics