ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE

Document Type : Original Article

Authors

1 Department of Medical Biochemistry, Faculty of Medicine, AL-Azhar University.

2 Department of Medical Biochemistry, Faculty of Medicine, AL-Azhar University

3 Department of Tropical Medicine, Faculty of Medicine, AL-Azhar University

Abstract

Hepatitis C virus(HCV) lifecycle is closely connected to host cell lipid metabolism, inducing oxidative stress and oxidation reaction induce chemical modification of proteins and lipids in plasma LDL transforming it to abnormal oxidized-LDL (Ox-LDL). Ox-LDL is more stable marker molecule with longer half-life than free radicals. This study assessed its contribution to the pathogenesis of liver diseases, and liver cirrhosis. This work studied serum level of ox-L L to evaluate its role in chronic hepatitis C patients and its association with liver cirrhosis. Also, the level of serum total antioxidant status was determined to evaluate their role in the treatment. The study included 20 chronic hepatitis C patients, 20 chronic hepatitis C patients with liver cirrhosis and 20 controls (age, sex & anthropometric measures were matched). All patients and controls were males. Serum was used to estimate Ox-LDL total direct bilirubin, albumin, aminotransferases, total antioxidant capacity, Urea and creatinine.

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