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ABU EL-MAKAREM, M., EL-NOKALY, A., MOHAMED, S. (2017). ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE. Journal of the Egyptian Society of Parasitology, 47(3), 653-662. doi: 10.12816/jesp.2017.77725
MAHMOUD ABU EL-MAKAREM; ABDEL-AZIZ ABDEL-RAHMAN EL-NOKALY; SAYED FAROUK MOHAMED. "ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE". Journal of the Egyptian Society of Parasitology, 47, 3, 2017, 653-662. doi: 10.12816/jesp.2017.77725
ABU EL-MAKAREM, M., EL-NOKALY, A., MOHAMED, S. (2017). 'ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE', Journal of the Egyptian Society of Parasitology, 47(3), pp. 653-662. doi: 10.12816/jesp.2017.77725
ABU EL-MAKAREM, M., EL-NOKALY, A., MOHAMED, S. ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE. Journal of the Egyptian Society of Parasitology, 2017; 47(3): 653-662. doi: 10.12816/jesp.2017.77725

ROLE OF OXIDIZED LOW-DENSITY LIPOPROTEIN IN HEPATITIS C RELATED CHRONIC LIVER DISEASE

Article 20, Volume 47, Issue 3, Autumn 2017, Page 653-662  XML PDF (399.44 K)
Document Type: Original Article
DOI: 10.12816/jesp.2017.77725
Authors
MAHMOUD ABU EL-MAKAREM1; ABDEL-AZIZ ABDEL-RAHMAN EL-NOKALY2; SAYED FAROUK MOHAMED3
1Department of Medical Biochemistry, Faculty of Medicine, AL-Azhar University.
2Department of Medical Biochemistry, Faculty of Medicine, AL-Azhar University
3Department of Tropical Medicine, Faculty of Medicine, AL-Azhar University
Abstract
Hepatitis C virus(HCV) lifecycle is closely connected to host cell lipid metabolism, inducing oxidative stress and oxidation reaction induce chemical modification of proteins and lipids in plasma LDL transforming it to abnormal oxidized-LDL (Ox-LDL). Ox-LDL is more stable marker molecule with longer half-life than free radicals. This study assessed its contribution to the pathogenesis of liver diseases, and liver cirrhosis. This work studied serum level of ox-L L to evaluate its role in chronic hepatitis C patients and its association with liver cirrhosis. Also, the level of serum total antioxidant status was determined to evaluate their role in the treatment. The study included 20 chronic hepatitis C patients, 20 chronic hepatitis C patients with liver cirrhosis and 20 controls (age, sex & anthropometric measures were matched). All patients and controls were males. Serum was used to estimate Ox-LDL total direct bilirubin, albumin, aminotransferases, total antioxidant capacity, Urea and creatinine.
Keywords
Egypt; patients; HCV; Chronic liver disease; Ox-LDL; TAC
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