IMPACT OF DIABETIC CONTROL ON ACHIEVING SUSTAINED VIROLOGIC RESPONSE IN CHRONIC HCV PATIENTS RECEIVING DIRECT-ACTING ANTIVIRALS

Document Type : Original Article

Authors

Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.

Abstract

This study evaluated the effect of diabetic control on achieving sustained virologic response in patients with chronic hepatitis C virus infection who received direct-acting antivirals (Daclatasvir + Sofosbuvir ± Ribavirin). It included 100 patients with chronic HCV infection (Treatment naive patients). Patients were classified into 3 groups according to diabetic control; GI: non diabetics, GII: well controlled diabetics & GIII: poorly controlled diabetics. All were subjected to clinical and laboratory examinations, abdominal ultrasonography and calculation of FIB-4 score. PCR for HCV RNA was assessed prior to treatment, post treatment and 12 weeks post-treatment. The results showed insignificant differences between all groups as regards sustained virologic response. Overall sustained virologic response was achieved in 91% of patients including 91.8% of patients treated with Daclatasvir + Sofosbuvir and 89.7% of those treated with Daclatasvir + Sofosbuvir + Ribavirin.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 48, Issue 1
April 2018
Pages 207-2013

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