ASSESSMENT OF THE EFFECTOR ANTIBODIES AGAINST SCHISTOSOMA MANSONI AND THEIR IMPACT ON MEFLOQUINE EFFICACY

Document Type : Original Article

Authors

1 Departments of Medical Parasitology, Faculty of Medicine, Helwan University, Egypt.

2 Departments of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Abstract

Host immune response against Schistosoma mansoni is a major contributor in the process of resistance or susceptibility to re-infection, as well as the therapeutic response towards different antischistosomal drugs. This study evaluated the role of IgG &IgG4 as immune-logical marker of cure and their effect on anti-schistosomal mefloquine efficacy. Sixty Swiss albino mice were infected with Schistosoma cercaria and divided into four groups; non-infected, infected not treated, infected treated with praziquantel and infected treated with mefloquine. The effect of drugs was assessed parasitologically using Kato-Katz technique and immunologically by measuring the serum level of anti-Schistosoma IgG & IgG4 subclass. The results showed 83.5% significant egg count reduction in MFQ-treated infected group. Also, serum anti-soluble egg antigen (SEA) total IgG & IgG4 subclass levels in MFQ treated group were significantly different from infected control group & PZQ-treated infected group.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 48, Issue 1
April 2018
Pages 175-181

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