Praziquantel, the main schistosomiasis chemotherapy; cannot fully counteract the infection associated morbidity including hepatic fibrosis and its sequelae. A novel therapeutic strategy is mandatory. The current study is a novel trial to assess the immunomodulatory effect of Paeoniflorin (PAE) in combination to soluble egg antigen (SEA) in schistosomiasis mansoni murine model through; parasitological, histopathological, immunohistochemical and serological studies aiming to synergistic effect that not only eliminate the parasite but also ameliorate morbidity associated to infection. Forty laboratory bred Swiss albino male CD-1 mice were used. The mice were classified into five groups (8 mice each), control healthy, control infected, PAE treated (50 mg/kg/d), SEA vaccinated (50μ protein) and combined (PAE+SEA) groups. All mice groups were sacrified 10 weeks post infection. Our results showed marked decrease in egg count/gm stool, worm burden, granuloma diameter, tissue transforming growth factor-beta1 (TGF-β ) serum interleukin-13 (IL-13) associated with marked increase in the serum interferon-gamma (INF-γ) level in (PAE+SEA) combined group compared to all groups.
ABD EL-AAL, N., & ABD ELBARY, E. (2019). IMMUNOMODULATORY EFFECTS OF PAEONIFLORIN COMBINED TO SOLUBLE EGG ANTIGENS IN SCHISTOSOMIASIS MANSONI MURINE MODEL. Journal of the Egyptian Society of Parasitology, 49(2), 293-300. doi: 10.21608/jesp.2019.68133
MLA
NAGLAA FATHY ABD EL-AAL; EMAN HASSAN ABD ELBARY. "IMMUNOMODULATORY EFFECTS OF PAEONIFLORIN COMBINED TO SOLUBLE EGG ANTIGENS IN SCHISTOSOMIASIS MANSONI MURINE MODEL". Journal of the Egyptian Society of Parasitology, 49, 2, 2019, 293-300. doi: 10.21608/jesp.2019.68133
HARVARD
ABD EL-AAL, N., ABD ELBARY, E. (2019). 'IMMUNOMODULATORY EFFECTS OF PAEONIFLORIN COMBINED TO SOLUBLE EGG ANTIGENS IN SCHISTOSOMIASIS MANSONI MURINE MODEL', Journal of the Egyptian Society of Parasitology, 49(2), pp. 293-300. doi: 10.21608/jesp.2019.68133
VANCOUVER
ABD EL-AAL, N., ABD ELBARY, E. IMMUNOMODULATORY EFFECTS OF PAEONIFLORIN COMBINED TO SOLUBLE EGG ANTIGENS IN SCHISTOSOMIASIS MANSONI MURINE MODEL. Journal of the Egyptian Society of Parasitology, 2019; 49(2): 293-300. doi: 10.21608/jesp.2019.68133