1
Department Medical Parasitology, Faculty of Medicine, Tanta University, Egypt
2
Department of Histology and Cell Biology, Faculty of Medicine, Tanta University, Egypt
10.21608/jesp.2025.447406
Abstract
Cryptosporidium parvum, a worldwide zoonotic parasite and in immunosuppressed patients can be fatal. Nitazoxanide® (NTZ) is effective in immunocompetent patients, but unsatisfactory in im munosuppressed ones. This study evaluated nitrofurantoin® (NF) as an anti-cryptosporidial drug in immunosuppressed mice. A total of 100 immunosuppressed mice were divided into 5 groups of 20 mice each: GI: neither infected nor treated, GII: infected non-treated, GIII: infected and NTZ (250mg/kg/day) treated, GIV: infected and NF 100mg/kg/day) treated, and GV: infected and NTZ & NF treated. All drugs were given orally on 4th day post infection (P.I.) for 7 consecutive days, and then mice were gent- ly sacrificed for parasitological, histopathological, ultra-structural and biochemical assessment af- ter one and two weeks post treatment (i.e. 11th & 18th day P.I.) GV showed the highest oocysts reduction count (65.7%, & 80%), followed by GIV (48.6%, & 59.8%) but, GIII showed the least effect (25.4%, & 30.2%) on 11th, & 18th day P.I. respectively. Histopathological and TEM examinations showed marked restoration of normal intestinal struct- ure in GV, followed by significant improvement in GIV, but GIII showed partial improvement with persistent dysplastic changes in enterocytes and marked ultra-structural abnormalities. Both NTZ &NF showed significant reduction of MDA level, however, NF was more effective in elev- ating GSH level than NTZ. Both NF & NTZ restored normal liver levels of SGOT & SGPT, compared to significantly increase positive control, normal kidneys levels of urea & creatinine.
BARAKAT, A., ASHOUR, D., ELBAKARY, R., & ELGENDY, W. (2025). EVALUATION OF THE EFFECT OF NITROFURANTOIN ON EXPERIMENTAL CRYPTOSPORIDIUM PARVUM INFECTION IN IMMUNOSUPPRESSED MICE. Journal of the Egyptian Society of Parasitology, 55(2), 269-279. doi: 10.21608/jesp.2025.447406
MLA
ASMAA M. BARAKAT; DALIA S. ASHOUR; REDA H. ELBAKARY; WESAM M. A. ELGENDY. "EVALUATION OF THE EFFECT OF NITROFURANTOIN ON EXPERIMENTAL CRYPTOSPORIDIUM PARVUM INFECTION IN IMMUNOSUPPRESSED MICE", Journal of the Egyptian Society of Parasitology, 55, 2, 2025, 269-279. doi: 10.21608/jesp.2025.447406
HARVARD
BARAKAT, A., ASHOUR, D., ELBAKARY, R., ELGENDY, W. (2025). 'EVALUATION OF THE EFFECT OF NITROFURANTOIN ON EXPERIMENTAL CRYPTOSPORIDIUM PARVUM INFECTION IN IMMUNOSUPPRESSED MICE', Journal of the Egyptian Society of Parasitology, 55(2), pp. 269-279. doi: 10.21608/jesp.2025.447406
VANCOUVER
BARAKAT, A., ASHOUR, D., ELBAKARY, R., ELGENDY, W. EVALUATION OF THE EFFECT OF NITROFURANTOIN ON EXPERIMENTAL CRYPTOSPORIDIUM PARVUM INFECTION IN IMMUNOSUPPRESSED MICE. Journal of the Egyptian Society of Parasitology, 2025; 55(2): 269-279. doi: 10.21608/jesp.2025.447406
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