ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE

ATEEQ, NAYERA S.; HUSSEIN, EMAN M.; YAHAI, NEHAL S.; ELZAGAWY, SHERINE

doi:10.21608/jesp.2025.447398

ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE

Document Type : Original Article

Authors

¹ Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt

² Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt.

³ Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Ismailia Governorate, Egypt.

10.21608/jesp.2025.447398

Abstract

In Egypt, cystic echinococcosis (CE) is a public health problem that categorizes patients into
susceptible or resistant groups referring to the immune system, particularly human leukocytic
antigen (HLA) Class I & II. In the present study, relation between non-classical HLA -G alleles
and the CE was achieved in a retrospective case-control study in Ismailia province. The study
included 33 diseased and Control groups matching age, sex, and residence. To identify HLA-G
alleles, Polymerase Chain Reaction (PCR) was performed. The frequency of non-classical
HLA-G alleles indicated a significant difference between the two study groups in only two
(0103 and 0105) out of seven. Allele 0103 was absent in 17 out of 33 (54.5%) patients, while it
lacked in 2 control persons (6.1%), however the allele 0105 was lacking in 16 out of 33
(48.5%) patients, while it missed in 3 control persons (9.1%). Regarding cyst sizes, < 5 cm and
≥ 5 cm showed significant differences. There were no significant differences in HLA-G distri
bution concerning the affected organs.

Keywords