EFFECT OF PROBIOTICS IN MICE EXPERIMENTALLY INFECTED WITH CRYPTOSPORIDIOSIS AND ITS RELATION TO COLON CANCER

Authors

1 Department of Medical Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

2 Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Probiotics are live microorganisms that offer health benefits. This study evaluated the crypto
sporidiosis parasitic burden in experimentally infected mice received probiotics and its poten
tial link to cancer. A total of six groups were included: Four were cryptosporidiosis-infected 
mice (30 mice each) and two control groups (10 mice each). The infected groups were immu
nocompetent mice without probiotics (G1), or with probiotics (G2), and immunocompro
omised mice without probiotics (G3) or with probiotics (G4). Cryptosporidiosis was diagnosed 
weeks 2 to 14 post-infection.  
The results showed that in G1, medium parasitic burden was 50% at week 2 and gradually 
declined to 0% by week 10, but heavy burden started at 33.4% in week 2 and dropped to 0% by 
week 4. In G2, medium burden decreased from 50% at week 4 to 33.4% by week 14, whereas 
heavy burden, which began at 50% in week 2, peaked at 66.6% by week 14, with significant 
difference between them. For G3, medium burden was 66.6% at week 2 and declined to 50% 
by week 14, but heavy burden increased from 33.4% at week 2 to 50% at week 14. In G4, med
ium burden fluctuated, decreased from 16.7% at week 2 to 33.4% at week 14, but heavy burden 
declined from 83.3% at week 2 to 66.6% at week 14. However, the changes were insignificant. 
Regarding dysplastic changes, no dysplasia was observed in G1. In G2, four out of five (80%) 
dysplastic mice had a heavy parasitic burden. In G3, 66.6% (4/6) of dysplastic mice exhibited a 
heavy burden, but in G4, 78.6% (11/14) of dysplastic mice had a heavy burden, without signifi
cant differences  

Keywords

Files

Share

How to cite

Statistics