Document Type : Original Article
Authors
1
Department of Medical Parasitology, Faculty of Medicine, Menoufia University, Egypt
2
Department of Immunology and Drug Evaluation, Theodor Bilharz Research Institute (TBRI), Imbaba, Egypt
3
Department of Applied Organic Chemistry, Chemical Industries Research Institute, National Research Centre, Dokki, Giza, Egypt
4
Department of Clinical and Molecular Parasitology, National Liver Institute, Menoufia University, Menoufia Governorate, Egypt
Abstract
One of the zoonotic health problem affecting is cryptosporidiosis. There is currently no
approved treatment for cryptosporidiosis, apart from nitazoxanide (NTZ). This study evaluated
the anti-protozoan and immune-modulating properties role of spirulina and probiotics, either
alone or loaded on Cu-MOF, against Cryptosporidium in immunocompromised mice compared
to NTZ. Seventy-eight male laboratory-bred pathogen-free, Swiss-albino mice were divided
into seven groups each of 12 mice except negative control one with six mice as follows: GI:
infected-untreated (positive control), GII: infected and Spirulina treated, GIII: infected and
probiotics treated, GIV: infected and NTZ treated, GV: infected and Spirulina loaded on Cu
BTC MOF treated, GVI: infected and probiotics loaded on Cu-BTC MOF treated, GVII:
neither infected nor treated (negative control). Drug efficacy was parasitological, biochemical
and histopathological evaluated.
The results showed that all drugs significantly reduced oocysts' count and intestinal parasite
burden as well as improved pathological squeals compared to corresponding infected mice.
There was a decrease in amyloid and neopterin sera levels in treated mice compared to infected
ones. NTZ gave the best treated results, followed by Spirulina nano formulation.
Keywords
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