VONOPRAZAN VERSUS PROTON PUMP INHIBITORS IN COMBINATION WITH ANTIBIOTICS AS A TRIPLE THERAPY FOR ERADICATION OF CLARITHROMYCIN RESISTANT STRAIN OF HELICOBACTER PYLORI

Document Type : Original Article

Authors

Department of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, 11566 Cairo, Egypt

Abstract

Generally, the common etiology of gastritis infection with Helicobacter pylori (H. pylori) is increasing.
Vonoprazan inhibits the activity of H+/K+ ATPases, with greater effect than PPIs on
decreasing gastric acidity. This randomized controlled study was performed on two Egyptian patients
groups: G1: 160 patients treated with Vonoprazan, Levofloxacin and Amoxicillin for two weeks, and
G2: 160 pat-ients treated with Pantoprazole, Levofloxacin andAmoxicillin for two weeks. Testing
fecal H. pylori Ag for all patients was done 8 weeks later after the completion of treatment course.
The results showed that 136 of 160(85%) patients were negative for H. pylori Ag in G1 compared to
112/160(70%) patients in G2 with the In intention to treat (ITT) analysis and per-protocol (PP)
analysis, for eradication rates was in G1greater than in G2 (P = 0.004, 0.002), respectively.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 54, Issue 2
August 2024
Pages 313-318

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