THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE

Document Type : Original Article

Authors

1 Department of Parasitology, Faculty of Medicine, Menoufia University, Egypt

2 Department of Pharmacology, Faculty of Medicine, Menoufia University, Egypt

3 Department of Public Health and Community Medicine

4 Department of Pathology, Faculty of Medicine, Menoufia University, Egypt

Abstract

Trichinosis is a common infection that spreads primarily through food. None of the therapies,
including albendazole (ALZ), have significant effectiveness against Trichinella spiralis larvae
encapsulated in muscle, so there is a need to find new, effective trichinosis medications. Acacia
nilotica (A. nilotica) is linked to many biological activities as anti-inflammatory, anti-microbial
and anti-carcinogenic activities. This study determined the efficacy of A. nilotica alone or in
combination with ALZ for treating intestinal and muscular trichinosis.
In this study, fifty mice were divided into five groups, non-infected control group, T. spiralis
infected control group, A. nilotica-treated group, ALZ treated group and finally Acacia-ALZ
treated group. Adult count, larval load, intestinal and muscular histology, COX2 expression, and
measurement of CD4+ & CD8+ lymphocytes percentages were investigated.
The results showed that mice received the combined therapy achieved the greatest outcomes in
terms of the criteria employed. ALZ was better than Acacia for intestinal trichinosis, although
Acacia was better for muscular trichinosis.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 54, Issue 2
August 2024
Pages 187-196

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