STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE

Authors

1 Department of Medical Parasitology, Faculty of Medicine, Benha University, Benha

2 Department of Immunology and drug evaluation, Theodor Bilharz Research Institute, Giza, Egypt

Abstract

Globally trichinellosis (Trichinella species) is a risky parasitic zoonosis Anthelminthic such as
oral albendazole® and mebendazole® commonly used to treatment are poorly water soluble with
unfavo- rable bioavailability. This study evaluated the therapeutic efficacy of lactoferrin loaded
on silver nanoparticles on Trichinella spiralis infection in experimental infected mice by parasitological
and histopathological parameters. Mice were classified into 8 groups each of 5 mice.
G1: Non infected non treated (normal), G2: Infected non treated (infected control), G3: In-fected
and albendazole, treated, G4: Infected and lactoferrin treated, G5: Infected and silver nanoparticles
treated, G6: Infected and lactoferrin loaded on silver nanoparticles treated, G7: Infected
and albendazole & lactoferrin, & G8: Infected and albendazole combined with lactoferrin
loaded on silver nanoparticles treated.
The results showed a significant decrease in all treated groups, markedly in T. spiralis larval
muscles treated with combination of albendazole and lactoferrin loaded on silver nanoparticles
(92.39%), with muscles histopathological changes

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