SAFETY OF BEE VENOM PREPARATION FOR MARKETING STRATEGY

Authors

1 VASCERA Holding Company for Biological Products & Vaccines, Giza P.O.Box, 276, Postal Code, 12311

2 Faculty of Biotechnology October University for MSA, Giza

3 Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt

Abstract

Bee venom is very popular; being a natural treatment with multiple medicinal effects for
several diseases. Research continues to endorse and reveal more of its benefits on human health.
This study assessed the safety of bee venom aqueous preparation by hematological, biochemical
and histopathological examinations. 20 male rabbits classified into control and test; were given
multiple bee venom intradermal injections according to a specific immunization schedule adopted
by VACSERA for 6 months and compared with control group injected with saline.
The hematological results showed improving in the red blood cells integrity leading to an increase
in erythron count. But, leukon showed a non-significant increase, yet lymphocytic count
significantly increased. Biochemical parameters revealed significant increase in total protein and
albumin within normal level accompanied with non-significant hyperglobulinemia. Total bilirubin,
direct bilirubin, aspartate transaminase, gamma glutamyl transferase, serum Iron level, creatine
phosphokinase and lactate dehydrogenase showed non-significant change, however serum
creatinine showed significant decrease. The histopathological findings showed normal picture of
liver, kidney, spleen tissues and heart muscles. The skin showed local allergic reaction but only
at the site of injection. From the aforementioned results bee venom was considered as a safe
medication.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 53, Issue 2
August 2023
Pages 359-368

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