ASSESSMENT OF METHANOLIC PLANT EXTRACT OF ALHAGI MAURORUM IN TREATING TRICHINELLA SPIRALIS INFECTIED MICE

SAAD, HAGER F. A.; HEGAZY, MOHAMED FATHY ABOUEL-NOUR; EL-SHEWEHY, DINA M. M.

doi:10.21608/jesp.2023.312131

ASSESSMENT OF METHANOLIC PLANT EXTRACT OF ALHAGI MAURORUM IN TREATING TRICHINELLA SPIRALIS INFECTIED MICE

Authors

Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Dakahlia Governorate, Egypt

10.21608/jesp.2023.312131

Abstract

Trichinella spiralis is a recurrent parasite that infects people everywhere. This work compared
the usage of methanolic extract of Alhagi maurorum versus Albendazole in treating
trichinellosis in experimental infected mice. Mice (72) were divided in to six groups: CN: Negative
control (non-infected-untreated), C-Alb: Mice treated with albendazole but not infected,
C-Alhag: Mice treated with methanolic extract of Alhagi, but not infected, CI: Positive control
(infected, not treated), T-Alb: Mice were infected then treated with Albendazole, T-Alhag: mice
were infected then treated with methanolic extract of A. maurorum. Mice were infected orally
with T. spiralis larvae at a dose of 300 larvae/ mouse except control untreated groups. On 7th
day post infection half of the groups were sacrificed for intestinal phase and the second half
were sacrificed on t 35th day post infection for the muscular phase. Treatment efficacy was determined
by parasitological and immunological parameters. The results showed that A. maurorum
treated mice gave lowest number of T. spiralis. The counts of adult in intestine and larval
in muscle, and immunologic data showed lowest levels of IFN-γ, TNF-α, TGF-β, IL-4, IL-2 &
IL-12 and highest level of IL-10 than infected control mice.

Keywords