EFFICACY OF MURINE PLATELET RICH-PLASMA VERSUS SPIRAMYCIN IN TREATMENT OF CHRONIC TOXOPLASMOSIS INFECTED MICE

Authors

Department of Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

Apicomplexan parasite, Toxoplasma gondii, is an obligate intracellular parasite, infecting
and replicating within nucleated cells in many homoeothermic organisms, mammals and birds
with the possibility of causing serious health problems. Recent studies indicated several side
effects to the current drugs like Pyrimethamine® & Sulfadiazine®. This work evaluated murine
platelet rich plasma (PRP) efficacy versus Spiramycin® treating toxoplasmosis infected
mice parasitological, biochemical and histopathological studies. Fifty five immunocompetent
male mice were divided into 5 groups of 11 mice each. G1: non-infected control, G2: infected
non-treated control, G3: infected and treated with spiramycin, G4: infected and treated with
murine PRP, and G5: infected and treated with combined spiramycin and PRP.
Spiramycin and PRP treated mice gave the highest reduction in Toxoplasma tissue cysts number,
lowest level of serum malondialdehyde (MDA) and marked pathological improvement.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 52, Issue 2
August 2022
Pages 267-278

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