EFFECT OF LACTOBACILLUS ACIDOPHILUS ON TRICHINELLA SPIRALIS MUSCLE LARVAE IN EXPERIMENTALLY INFECTED MICE COMPARED TO ITS EFFECT WHEN COMBINED WITH ALBENDAZOLE AND/OR NITAZOXANIDE

Document Type : Original Article

Authors

1 Department of Medical Parasitology, Faculty of Medicine, Cairo University, Egypt

2 Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Abstract

This study evaluated the therapeutic and synergistic effects of Lactobacillus acidophilus (L.
acidophilus), a probiotic, and nitazoxanide (NTZ) as compared to the used, albendazole (ABZ),
as single therapy and in combination. ABZ/L. acidophilus-treated group showed the highest
reduction of encysted larvae (92.5%) as compared to control and to ABZ-treated mice. Also,
NTZ treatment showed a significant decrease in larval counts compared to control (40.95%),
which was comparable to that produced by L. acidophilus single therapy. But, combined NTZ
with L. acidophilus caused a significantly higher reduction of larvae (56.62%) highlighted synergistic
abilities of both. Histopathological examination showed marked decrease in larval
counts and inflammatory reactions in ABZ/L. acidophilus-treated group. Combined L. acidophilus
with other therapeutics caused increased eosinophilia degeneration and larval replacement.

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