Chronic toxoplasmosis is associated with psychotic disorders. Multiple in vitro studies showed that many antipsychotic medications have anti-Toxoplasma activity. Meanwhile, there is very limited data regarding the inhibitory effect of them on Toxoplasma in vivo. This study evaluated the activity of Chlorpromazine®, Clozapine®, and prolactin (a pituitary gland hormone) on toxoplasmosis infected rats. Clean laboratory breed rats were chronically infected with non-virulent T. gondii strain and classified into 8 groups: negative, positive control groups, chlorpromazine, clozapine, and metoclopramide drug control groups, and 3 infected treated groups. Rats’ sera were screened with ELISA test to evaluate level of dopamine, interferon gamma, and prolactin. All drugs were effective against T. gondii in infected rats. Dopamine level and INF-γ level were significantly decreased in chlorpromazine infected treated rats. There was significant decrease of dopamine level and increase of prolactin level in clozapine infected treated rats. In metoclopramide infected treated rats prolactin level significantly increased, but INF-γ level significantly decreased.
Deeb, A., HASSAN, A. A., TOLBA, M. E. M., & HUSEEIN, E. A. (2021). THE EFFECTS OF TWO ANTIPSYCHOTIC DRUGS AND PROLACTIN ON TOXOPLASMA GONDII TACHYZOITES IN VIVO. Journal of the Egyptian Society of Parasitology, 51(2), 355-364. doi: 10.21608/jesp.2021.193315
MLA
Asmaa Hosney Deeb; ABD-ALLAH ABD-ELSAMEE HASSAN; MOHAMED E. M. TOLBA; ENAS A. HUSEEIN. "THE EFFECTS OF TWO ANTIPSYCHOTIC DRUGS AND PROLACTIN ON TOXOPLASMA GONDII TACHYZOITES IN VIVO". Journal of the Egyptian Society of Parasitology, 51, 2, 2021, 355-364. doi: 10.21608/jesp.2021.193315
HARVARD
Deeb, A., HASSAN, A. A., TOLBA, M. E. M., HUSEEIN, E. A. (2021). 'THE EFFECTS OF TWO ANTIPSYCHOTIC DRUGS AND PROLACTIN ON TOXOPLASMA GONDII TACHYZOITES IN VIVO', Journal of the Egyptian Society of Parasitology, 51(2), pp. 355-364. doi: 10.21608/jesp.2021.193315
VANCOUVER
Deeb, A., HASSAN, A. A., TOLBA, M. E. M., HUSEEIN, E. A. THE EFFECTS OF TWO ANTIPSYCHOTIC DRUGS AND PROLACTIN ON TOXOPLASMA GONDII TACHYZOITES IN VIVO. Journal of the Egyptian Society of Parasitology, 2021; 51(2): 355-364. doi: 10.21608/jesp.2021.193315