EVIDENCE OF ANTI-DOUBLE STRANDED DNA ANTIBODIES AND C-REACTIVE PROTEIN IN EGYPTIAN PATIENTS WITH HIGH ANTI-SCHISTOSOMA MANSONI ANTIBODY TITER

FADL, HANAA O.; ISMAIL, MOUSA A. M.; EL SAFTAWY, ENAS A.

doi:10.21608/jesp.2021.165956

EVIDENCE OF ANTI-DOUBLE STRANDED DNA ANTIBODIES AND C-REACTIVE PROTEIN IN EGYPTIAN PATIENTS WITH HIGH ANTI-SCHISTOSOMA MANSONI ANTIBODY TITER

Document Type : Original Article

Authors

Department of Medical Parasitology

10.21608/jesp.2021.165956

Abstract

Schistosomiasis is one of the major public health diseases that induced a diversity of immunologic
reactions. Significant association between autoreactive antibodies and autoimmune disorders
was suggested. This study investigated the presence of anti-double stranded DNA (anti-ds
DNA) antibodies and inflammatory biomarker, C-reactive protein (CRP) in 89 Egyptian patients,
with Schistosoma mansoni clinical evidence and high anti-Schistosoma antibody titer. The
results showed positive serum anti-ds DNA antibodies in 11/89(12.4%) of them, without significance
to age, sex or anti-Schistosoma antibody titers. CRP was positive in 20/89(22.5%) of patients,
with significant correlation with anti-ds DNA antibodies (P=0.000).

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