ASSESSMENT OF THE EFFECT OF ALLIUM SATIVUM (GARLIC) AND CURCUMA LONGA (CURCUMIN) IN COMBINATION WITH DRUGS O N CULTURED TRICHOMONAS VAGINALIS

Document Type : Original Article

Authors

1 Department of Medical Parasitology, Faculty of Medicine, Assiut University, Egypt

2 Department of Gynecology and Obstetrics,Aswan University, Egypt

3 Department of Medical Parasitology, Faculty of Medicine Aswan University, Egypt

4 Department of Medical Parasitology, Faculty of Medicine, Assiut University, 71515 Assiut, Egypt

Abstract

Trichomoniasis is an infectious disease caused by Trichomonas vaginalis. It inflicts severe complications
to human genitourinary system. The devastating negative effects and resistance emerged
to known medication impose the search for effective and safer alternatives. This study evaluated
the effect of curcumin and garlic as well as combination between their effective doses
with Metronidazole® & Tinidazole®. So, vaginal swabs were obtained from the symptomatic
patients, and cultured on modified Diamond's medium. Assessment of the herbs various concentrations
at different follow-up periods was done by counting dead T. vaginalis trophozoites
by using hemocytometer and trypan blue staining. The results showed that curcumin 400mg/ml
gave a promising anti-Trichomonas especially when combined with garlic 90mg/ml that showed a
high synergistic effect.

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