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Journal of the Egyptian Society of Parasitology
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Volume Volume 50 (2020)
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MOHAMED, R., EL-KARMOUTY, K., AHMED, M., ESKANDAR, E., El KILANY, H., RASMY, H. (2020). RISK FACTORS ASSOCIATED WITH DELISTING OF HEPATOCELLULAR CARCINOMA PATIENT'S CANDIDATES FOR LIVER TRANSPLANTATION. Journal of the Egyptian Society of Parasitology, 50(3), 706-711. doi: 10.12816/jesp.2020.131119
RASHA SAMIR MOHAMED; KHALED ZAKARIA EL-KARMOUTY; MOHAMED MOHAMED BAHAA ELDIN AHMED; ENGY EZZAT ESKANDAR; HESHAM HAMDY El KILANY; HANY SAMIR RASMY. "RISK FACTORS ASSOCIATED WITH DELISTING OF HEPATOCELLULAR CARCINOMA PATIENT'S CANDIDATES FOR LIVER TRANSPLANTATION". Journal of the Egyptian Society of Parasitology, 50, 3, 2020, 706-711. doi: 10.12816/jesp.2020.131119
MOHAMED, R., EL-KARMOUTY, K., AHMED, M., ESKANDAR, E., El KILANY, H., RASMY, H. (2020). 'RISK FACTORS ASSOCIATED WITH DELISTING OF HEPATOCELLULAR CARCINOMA PATIENT'S CANDIDATES FOR LIVER TRANSPLANTATION', Journal of the Egyptian Society of Parasitology, 50(3), pp. 706-711. doi: 10.12816/jesp.2020.131119
MOHAMED, R., EL-KARMOUTY, K., AHMED, M., ESKANDAR, E., El KILANY, H., RASMY, H. RISK FACTORS ASSOCIATED WITH DELISTING OF HEPATOCELLULAR CARCINOMA PATIENT'S CANDIDATES FOR LIVER TRANSPLANTATION. Journal of the Egyptian Society of Parasitology, 2020; 50(3): 706-711. doi: 10.12816/jesp.2020.131119

RISK FACTORS ASSOCIATED WITH DELISTING OF HEPATOCELLULAR CARCINOMA PATIENT'S CANDIDATES FOR LIVER TRANSPLANTATION

Article 29, Volume 50, Issue 3, Autumn 2020, Page 706-711  XML PDF (781.83 K)
Document Type: Original Article
DOI: 10.12816/jesp.2020.131119
Authors
RASHA SAMIR MOHAMED1; KHALED ZAKARIA EL-KARMOUTY1; MOHAMED MOHAMED BAHAA ELDIN AHMED2; ENGY EZZAT ESKANDAR1; HESHAM HAMDY El KILANY1; HANY SAMIR RASMY1
1Department of Internal Medicine
2Department of Surgery
Abstract
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with more
than 1 million new cases diagnosed every year. Liver transplantation has been used as a curative
treatment for patients with HCC.
Liver transplantation offers the best cure chance for unrespectable hepatocellular carcinoma
(HCC), but the scarcity of cadaver liver grafts has seriously limited its role. With the recent advances
in adult living donor liver transplantation (LDLT), there is potentially a drastic change in
the role of liver transplantation. Recent Studies have demonstrated the theoretical survival benefit
of LDLT over deceased donor liver transplantation (DDLT) which depends largely on the
waiting time and drop‐out rate. This study was conducted to analyze the different risk factors
leading to delisting in liver transplant patients with hepatocellular carcinoma. Fifty patients presented
to Ain Shams Specialized Hospitals from January 2017 to June 2018, with expected average
hepatocellular carcinoma eligible for Adult Living Donor Liver transplantation (ALDLT) were
studied. They were evaluated according to protocol of Ain Shams Center of Organ Transplantation
(ASCOT). Inclusion criteria: 1-hepatocellular carcinoma with any underlying cause of
cirrhosis. HCC is first diagnosed using spiral computed tomography of liver and sometimes
Magnetic Resonance Imaging (MRI). 2- Patients within University of California San Francisco
(UCSF) criteria (one tumor ≤6·5 cm, three nodules with largest ≤4·5cm, & total tumor diameter
≤8 cm). 3- Patients within these criteria underwent loco-regional therapy as bridging therapy including
radiofrequency ablation, radio-embolization, trans-arterial chemoembolization, microwave
ablation or liver resection to avoid delisting. 4- Patients beyond these criteria underwent
loco-regional treatment as means of down staging to be within Milan or UCSF and candidates
for ALDLT. Exclusion criteria: 1- metastatic HCC patients, 2- macrovascular invasion, & 3-
poor general condition for surgery.
Keywords
Transplantation; Priority; Hepatocellular carcinoma; Delisting
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