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Journal of the Egyptian Society of Parasitology
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Volume Volume 50 (2020)
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BRAKAT, R., SOLIMAN, S., SHARAF-EL-DEEN, S. (2020). EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI. Journal of the Egyptian Society of Parasitology, 50(3), 664-672. doi: 10.12816/jesp.2020.131106
REHAM MUSTAFA BRAKAT; SHAIMAA SHERIF SOLIMAN; SHAIMAA AHMED SHARAF-EL-DEEN. "EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI". Journal of the Egyptian Society of Parasitology, 50, 3, 2020, 664-672. doi: 10.12816/jesp.2020.131106
BRAKAT, R., SOLIMAN, S., SHARAF-EL-DEEN, S. (2020). 'EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI', Journal of the Egyptian Society of Parasitology, 50(3), pp. 664-672. doi: 10.12816/jesp.2020.131106
BRAKAT, R., SOLIMAN, S., SHARAF-EL-DEEN, S. EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI. Journal of the Egyptian Society of Parasitology, 2020; 50(3): 664-672. doi: 10.12816/jesp.2020.131106

EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI

Article 24, Volume 50, Issue 3, Autumn 2020, Page 664-672  XML PDF (1.47 MB)
Document Type: Original Article
DOI: 10.12816/jesp.2020.131106
Authors
REHAM MUSTAFA BRAKAT1; SHAIMAA SHERIF SOLIMAN2; SHAIMAA AHMED SHARAF-EL-DEEN3
1Department of Parasitology1, and Department of Public Health and Community Medicine
2Faculty of Medicine, Menoufia University, Egypt
3Department of Parasitology
Abstract
Schistosomiasis is the second commonest parasitic disease worldwide. It is responsible for thousands
of deaths per year in addition to the associating serious morbidities that burden both individuals and
communities. To date, the main preventive measure of infection is mass treatment with praziquantel. it
carries the risk of reinfection and rising resistance which makes the discovery of an effective vaccine
an urgent necessity. The present study evaluated E. camaldulensis killed cercariae immunogen (KCI)
as a candidate vaccine for experimental schistosomiasis mansoni and to detect the possible immunological
mechanisms of action of this immunogen. The KCI caused a significant reduction of both
schistosomula and adult worm counts with subsequent ova count reduction. Hepatic granulomas were
reduced in number or size. Also, levels of IgG, IgG1 & IgG2a as well as INF-γ & IL-10 fluctuated
larger than in natural infection.
Keywords
Eucalyptus Camaldulensis; killed cercariae vaccine; Schistosoma mansoni
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