BRAKAT, R., SOLIMAN, S., SHARAF-EL-DEEN, S. (2020). EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI. Journal of the Egyptian Society of Parasitology, 50(3), 664-672. doi: 10.12816/jesp.2020.131106
REHAM MUSTAFA BRAKAT; SHAIMAA SHERIF SOLIMAN; SHAIMAA AHMED SHARAF-EL-DEEN. "EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI". Journal of the Egyptian Society of Parasitology, 50, 3, 2020, 664-672. doi: 10.12816/jesp.2020.131106
BRAKAT, R., SOLIMAN, S., SHARAF-EL-DEEN, S. (2020). 'EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI', Journal of the Egyptian Society of Parasitology, 50(3), pp. 664-672. doi: 10.12816/jesp.2020.131106
BRAKAT, R., SOLIMAN, S., SHARAF-EL-DEEN, S. EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI. Journal of the Egyptian Society of Parasitology, 2020; 50(3): 664-672. doi: 10.12816/jesp.2020.131106
EVALUATION OF THE EUCALYPTUS CAMALDULENSIS-KILLED CERCARIAE AS A CANDIDATE VACCINE FOR EXPERIMENTAL SCHISTOSOMIASIS MANSONI
1Department of Parasitology1, and Department of Public Health and Community Medicine
2Faculty of Medicine, Menoufia University, Egypt
3Department of Parasitology
Abstract
Schistosomiasis is the second commonest parasitic disease worldwide. It is responsible for thousands of deaths per year in addition to the associating serious morbidities that burden both individuals and communities. To date, the main preventive measure of infection is mass treatment with praziquantel. it carries the risk of reinfection and rising resistance which makes the discovery of an effective vaccine an urgent necessity. The present study evaluated E. camaldulensis killed cercariae immunogen (KCI) as a candidate vaccine for experimental schistosomiasis mansoni and to detect the possible immunological mechanisms of action of this immunogen. The KCI caused a significant reduction of both schistosomula and adult worm counts with subsequent ova count reduction. Hepatic granulomas were reduced in number or size. Also, levels of IgG, IgG1 & IgG2a as well as INF-γ & IL-10 fluctuated larger than in natural infection.
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