PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA

Document Type : Original Article

Authors

1 Departments of Tropical Medicine

2 Departments of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt

Abstract

Intrahepatic distant recurrence, after successful radiofrequency ablation for hepatocellular
carcinoma, is related to many factors. Underlying liver fibrosis/cirrhosis severity thought to be
one of these contributors. FIB-4 index is a non-invasive marker which reflects the severity of
liver fibrosis. The aim of this study was to evaluate the prognostic value of FIB-4 index after
radiofrequency ablation for hepatocellular carcinoma with curative intent. This retrospective
study included 121 HCV related hepatocellular carcinoma patients with Child class A who underwent
radiofrequency ablation between 1/2010 & 12/2014. The study assessed the overall
survival and denovo intrahepatic distant recurrence using pretreatment FIB-4 index.
The result showed that pretreatment FIB-4 index of ≤3.25 patients had significant better free
intrahepatic distant recurrence and overall survival rates after radiofrequency ablation when compared
to those with pretreatment FIB-4 index of > 3.25, even in subsets of patients with Child
score 5, single lesion or lesions< 3cm. Also, FIB-4 index was useful prognostic predictor of intrahepatic
distant recurrence and overall survival after radiofrequency ablation in Child class A
patients in uni and multivraite analysis.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 50, Issue 3
December 2020
Pages 605-612

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