MONEM, E., EL-GHARIB, M., SAYED, A., ALBREEDY, A. (2020). PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA. Journal of the Egyptian Society of Parasitology, 50(3), 605-612. doi: 10.12816/jesp.2020.131093
EFFAT A. MONEM; MOHAMED EL-GHARIB; AHMED SAYED; ASHRAF M. ALBREEDY. "PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA". Journal of the Egyptian Society of Parasitology, 50, 3, 2020, 605-612. doi: 10.12816/jesp.2020.131093
MONEM, E., EL-GHARIB, M., SAYED, A., ALBREEDY, A. (2020). 'PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA', Journal of the Egyptian Society of Parasitology, 50(3), pp. 605-612. doi: 10.12816/jesp.2020.131093
MONEM, E., EL-GHARIB, M., SAYED, A., ALBREEDY, A. PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA. Journal of the Egyptian Society of Parasitology, 2020; 50(3): 605-612. doi: 10.12816/jesp.2020.131093
PROGNOSTIC IMPACT OF PRETREATMENT FIB-4 INDEX AFTER RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA
2Departments of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
Abstract
Intrahepatic distant recurrence, after successful radiofrequency ablation for hepatocellular carcinoma, is related to many factors. Underlying liver fibrosis/cirrhosis severity thought to be one of these contributors. FIB-4 index is a non-invasive marker which reflects the severity of liver fibrosis. The aim of this study was to evaluate the prognostic value of FIB-4 index after radiofrequency ablation for hepatocellular carcinoma with curative intent. This retrospective study included 121 HCV related hepatocellular carcinoma patients with Child class A who underwent radiofrequency ablation between 1/2010 & 12/2014. The study assessed the overall survival and denovo intrahepatic distant recurrence using pretreatment FIB-4 index. The result showed that pretreatment FIB-4 index of ≤3.25 patients had significant better free intrahepatic distant recurrence and overall survival rates after radiofrequency ablation when compared to those with pretreatment FIB-4 index of > 3.25, even in subsets of patients with Child score 5, single lesion or lesions< 3cm. Also, FIB-4 index was useful prognostic predictor of intrahepatic distant recurrence and overall survival after radiofrequency ablation in Child class A patients in uni and multivraite analysis.
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