ELGENDY, D., OTHMAN, A., EL-GUINDY, D., SOLIMAN, N., ELMEHY, D. (2020). SYNERGY BETWEEN BETA-1, 3-GLUCAN AND PRAZIQUANTEL IN THE TREATMENT OF EXPERIMENTAL CHRONIC SCHISTOSOMIASIS MANSONI. Journal of the Egyptian Society of Parasitology, 50(3), 565-574. doi: 10.12816/jesp.2020.131088
DINA I. ELGENDY; AHMAD A. OTHMAN; DINA M. EL-GUINDY; NEMA A. SOLIMAN; DALIA A. ELMEHY. "SYNERGY BETWEEN BETA-1, 3-GLUCAN AND PRAZIQUANTEL IN THE TREATMENT OF EXPERIMENTAL CHRONIC SCHISTOSOMIASIS MANSONI". Journal of the Egyptian Society of Parasitology, 50, 3, 2020, 565-574. doi: 10.12816/jesp.2020.131088
ELGENDY, D., OTHMAN, A., EL-GUINDY, D., SOLIMAN, N., ELMEHY, D. (2020). 'SYNERGY BETWEEN BETA-1, 3-GLUCAN AND PRAZIQUANTEL IN THE TREATMENT OF EXPERIMENTAL CHRONIC SCHISTOSOMIASIS MANSONI', Journal of the Egyptian Society of Parasitology, 50(3), pp. 565-574. doi: 10.12816/jesp.2020.131088
ELGENDY, D., OTHMAN, A., EL-GUINDY, D., SOLIMAN, N., ELMEHY, D. SYNERGY BETWEEN BETA-1, 3-GLUCAN AND PRAZIQUANTEL IN THE TREATMENT OF EXPERIMENTAL CHRONIC SCHISTOSOMIASIS MANSONI. Journal of the Egyptian Society of Parasitology, 2020; 50(3): 565-574. doi: 10.12816/jesp.2020.131088
SYNERGY BETWEEN BETA-1, 3-GLUCAN AND PRAZIQUANTEL IN THE TREATMENT OF EXPERIMENTAL CHRONIC SCHISTOSOMIASIS MANSONI
Praziquantel can develop resistance and cannot counteract schistosomiasis pathology. β-glucan was used as an immunomodulator for innate and acquired immunity. This study evaluated the effects of β-glucan either alone or with PZQ on chronic Schistosoma mansoni infection. Mice were divided into five groups: uninfected control, infected untreated, PZQ treated, β-glucan treated and combined treatment groups. Treatment started at the end of 8th week P.I. Parasitological, histopathological, immunohistochemical (α-SMA) studies and biochemical assays (Myeloperoxidase activity, NO, TNF-α, INF-γ, IL-13 & hydroxyproline) in liver tissues were done. Combination of β-glucan and PZQ therapy resulted in significant decrease in adults count, hepatic egg loads, granuloma number and diameter as well as significant improvement of hepatic pathology and reduction of hepatic fibrosis.
Top