ELGENDY, D., OTHMAN, A., SAIED, E., ZOGHROBAN, H. (2020). ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS. Journal of the Egyptian Society of Parasitology, 50(3), 467-476. doi: 10.12816/jesp.2020.130833
DINA ELGENDY; AHMAD OTHMAN; EMAN SAIED; HAGER ZOGHROBAN. "ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS". Journal of the Egyptian Society of Parasitology, 50, 3, 2020, 467-476. doi: 10.12816/jesp.2020.130833
ELGENDY, D., OTHMAN, A., SAIED, E., ZOGHROBAN, H. (2020). 'ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS', Journal of the Egyptian Society of Parasitology, 50(3), pp. 467-476. doi: 10.12816/jesp.2020.130833
ELGENDY, D., OTHMAN, A., SAIED, E., ZOGHROBAN, H. ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS. Journal of the Egyptian Society of Parasitology, 2020; 50(3): 467-476. doi: 10.12816/jesp.2020.130833
ASSESSMENT OF NEUROINFLAMMATORY AND NEURODEGENERATIVE ALTERATIONS IN THE BRAIN IN A MOUSE MODEL OF VISCERAL LARVA MIGRANS
1Department of Medical Parasitology, Faculty of Medicine, Tanta University. Egypt
2Department of Pathology, Faculty of Medicine, Kafrelsheikh University. Egypt
Abstract
Neurotoxocariasis is a parasitic zoonosis resulting from the intrusion of the larvae of dog roundworm Toxocara canis into the central nervous system (CNS), leading to severe CNS insults, and provoking different neurological manifestations ranging from headache to convulsions and paresis. This work assessed the probable occurrence of neuroinflammatory and neuro-degenerative alterations in the brain tissues of T. canis infected mice and evaluated the changes in brain parasite loads over the course of infection. The total larval loads in the brain, histopathological, immunohistochemical (MMP-3 & MMP-9) examination as well as determination of NFcell infiltration around larvae in brain tissues of mice, expressions of all the investigated markers of neuroinflammation and neurodegeneration showed an ascending pattern throughout the course of the infection and were directly proportional to the increase in the brain larval loads.
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