ANTHELMINTHIC EFFECT OF TAMOXIFEN ON EXPERIMENTALLY HYMENOLEPIS NANA INFECTED MICE

FAKAHANY, AMANY F.EL; IBRAHIM, MOHAMED H. S.; HUSSEIN, ATEF H.; EL SAWY, NAGLAA A. M.; ALI, HEMAT S. M.

doi:10.21608/jesp.2020.113057

ANTHELMINTHIC EFFECT OF TAMOXIFEN ON EXPERIMENTALLY HYMENOLEPIS NANA INFECTED MICE

Document Type : Original Article

Authors

Department of Parasitology, Faculty of Medicine, Benha University, Benha, Egypt

10.21608/jesp.2020.113057

Abstract

Hymenolepis nana is one of the commonest parasites worldwide especially in children. Praziquantel
was the most effective drug in hymenolepiasis treatment, but with the risk of resistance
development. There was a need for search for drug(s) to overcome this problem. Tamoxifen
(an estrogen-receptor modulator), is available, low cost with potential anti-parasitic efficacy.
This study assessed the therapeutic effect of tamoxifen drug on mice experimentally infected
mice with H. nana at different developmental stages. Clean laboratory bred mice infected with
H. nana eggs were divided into 4 groups according to different schedule of tamoxifen administration
(20mg/kg body weight) at the parasite different developmental stages and control one
(infected non treated). At the experimental mice were sacrificed and parasitological evaluated
for worm burden count, their weight, egg count and viability. The results did not show statistically
significant effect on worm burden as compared to control one, with the exception of mice
treated two days post-infection that showed significant increase in worm burden. There was
significant decrease in worm weight, egg count and viability as compared to control ones, but
without difference between different treated groups.

Keywords