MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI

SALAMA, MOHAMED MAGDY; MAKHLOUF, MOHAMED ALI; ELESSAWY, HAGAR AHMED; EL BADRY, MOHAMED MOHEI; ELFOULY, HEBA MAHMOUD

doi:10.21608/jesp.2020.113053

MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI

Document Type : Original Article

Authors

¹ Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

² Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Aswan University, Aswan,Egypt

³ Department of Internal Medicine, Hammoul Central Hospital, Kafr El Shaikh, Egypt

10.21608/jesp.2020.113053

Abstract

Chronic kidney disease (CKD) is a progressive condition that may negatively affect musculoskeletal
health. Secondary sarcopenia due to CKD may be associated with mobility limitations
and elevated fall risk. Thus, it is important to investigate surrogate methods that enable
the assessment of muscle mass. Myostatin regulates synthesis and degradation of skeletal muscle
proteins and is associated with the development of sarcopenia. This study assessed the myostatin
level in CKD patients and correlated with body mass index. This a prospective case
control study, carried out on 30 Egyptian patients with CKD (15 have post-HCV cirrhosis) attended
for dialysis in Al-Hammoul Central Hospital and 15 healthy controls. All patients were
subjected to detailed medical history and through clinical examination, abdominal ultrasound
and determination of serum myostatin level. The mean, standard deviation and chi-square were
calculated by SPSS. ROC curves were conducted to test the discriminative value of myostatin
level on sarcopenia and to detect the cut-off points. The results showed significant increase in
the serum myostatin level in hemodialysis patients. Myostatin level in post-HCV cirrhotic patients
was insignificantly higher than in non-cirrhotic patients. There was a significant negative
correlation between serum myostatin level and BMI and skeletal muscle index (SMI). ROC
curve showed that a cut off value of 39.05ng/ml can detect sarcopenia in hemodialysis patients.

Keywords