TY - JOUR ID - 297350 TI - PREVALENCE OF METABOLIC DYSFUNCTION- ASSOCIATED FATTY LIVER DISEASE IN EGYPTIAN PATIENTS WITH HEPATOCELLULAR CARCINOMA JO - Journal of the Egyptian Society of Parasitology JA - JESP LA - en SN - 1110-0583 AU - FARID, HODA MOHAMMED AU - BARAKAT, EMAN MAHMOUD AU - SHAKER, MOHAMMED KAMAL AU - ZAKY, DOAA ZAKARIA AU - MONTASSER, IMAN FAWZY AU - ABDELRAZIK, YASSER ARAFAT AD - Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt Y1 - 2023 PY - 2023 VL - 53 IS - 1 SP - 93 EP - 100 KW - Metabolic (dysfunction) associated fatty liver disease KW - Cirrhosis KW - Hepatocellular carcinoma DO - 10.21608/jesp.2023.297350 N2 - Hepatocellular carcinoma is the third common cause of mortality worldwide with majorchanges of the prevalence of different etiologies. Nowadays we found more conflicting dataabout metabolic dysfunction -associated fatty liver disease (MAFLD) and its effect on a majorspectrum of liver diseases as an increasing cause of hepatocellular carcinoma worldwide.The study was to assessed prevalence of MAFLD as a single causes of HCC among HCCpatients presented to the Hepatoma specialized outpatient clinic and to evalute effect on tumorburden and survival as compared to HCV infection patients related HCC.Twenty nine patients with MAFLD related HCC were included in group A while 58 patientswith HCV related HCC were enrolled as group B .In group (A) ; the mean age was 58.86(+8.47) years, this group included 20 male patients (68.97%) and 9 female patients (31.03%).While in group (B); the mean age was 60/05(+ 6.83) years, with 45 males (77.59%) and 13 females(22.41%) without significant difference between both as to age (P=0.482) or sexes(P=0.383). In the MAFLD related HCC group there were 19 /29 patients (65.5%) had Diabetesmellitus, 15 patients (51.7%) had hypertension and 9 patients (31%) were on antidyslipidimicdrugs. The mean Body mass index (BMI) was 29kg/m2 (±SD 2.81) Also, comparison betweengroups regarding tumor burden and characteristics of HCC, Child Pugh score, or Barcelonaclinic liver cancer (BCLC ) showed no significant statistical difference between both groupsexcept for lymph node metastases which was higher in patients with HCV related HCC.One year survival rate was higher in MAFLD group (72.4%) than of that in HCV related HCCgroup (58.6%) however, no significant statistical difference between both groups p=0.184 UR - https://jesp.journals.ekb.eg/article_297350.html L1 - https://jesp.journals.ekb.eg/article_297350_33e733e7b885845300f3e50dabb51f08.pdf ER -