CIPROFLOXACIN-LOADED SILVER NANOPARTICLES EFFICACY ON CHRONIC TOXOPLASMOSIS INFECTED MICE

Document Type : Original Article

Authors

Department of Medical Parasitology, Faculty of Medicine, Benha University, Egypt

Abstract

Toxoplasmosis is one of the commonest health problems especially in immunocompromised
patients. The study evaluated the effect of ciprofloxacin loaded on silver nanoparticles in treating
mice experimentally infected toxoplasmosis treatment of. This study was conducted on
mice infected with (ME 49 Toxoplasma gondii strain). Sixty mice were divided into: GI: 5 non
infected non-treated mice (normal control). GII: 10 infected non-treated mice (infected control).
GIII: 10 infected mice treated with Spiramycin 100mg/kg (drug controls). GIV: 10 infected
mice treated with ciprofloxacin 100mg/kg. GV: 10 infected mice treated with ciprofloxacin
loaded silver nano-particles (100mg/kg ciprofloxacin+2.5μg/kg silver nano). GVI: 10 infected
mice treated with silver nanoparticles (2.5μg/kg). GVII: 5 non-infected mice treated
with silver nanoparticles (2.5μg/kg). Mice were sacrificed 8 weeks (experimental end) and
brain and liver from each group were processed for histopathological studies of the cysts numbers,
and sizes.

Keywords

Journal of the Egyptian Society of Parasitology
Volume 52, Issue 3
December 2022
Pages 483-490

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